Sunday, July 26, 2009

Human Body Secretes Par4 Protein which can cure Cancer

Recently the news daily "The Times of India" had published an article on the breakthrough discovery of Dr. Vivek Rangnekar on the treatment of dangerous disease cancer. I felt it necessary to spread the news of this breakthrough discovery through my blog. Hope you find it useful.

A Mumbai born US-settled Dr. Vivek Rangnekar, professor of radiation medicine at the University of Kentucky, hit the headlines last year for creating the world's first breed of super mice, which are resistant to all forms of cancer.

Now he has in another breakthrough discovered that the Par-4 protein (a mass killer of cancer cells) is produced within the human body itself and spreads through circulation to distant organs.

This finding will now help scientists look at ways on how to naturally increase the secretion of the protein, for example, by certain natural diets and develop resistance to the growth of cancer. Scientists can also develop approaches to safely inject the Par-4 protein to inhibit cancer. The team headed by Dr. Rangnekar has also found that Par-4 protein is capable of killing cancer cells, when applied from outside.Till this discovery, scientists believed that Par-4 protein has to be present inside cancer cells to kill them. Since it isn't easy to deliver large amounts of the protein inside cancer cells, scientists have been studying other methods to target and kill cancer cells.

Par-4, after being secreted by the human tissues, has also been found to kill only cancer cells. It didn't harm normal cells, proving they aren't toxic. The presence of large amounts of Par4- protein in the super mice had made them completely invulnerable to cancer. Not only did they not develop tumours, they even lived longer.

According to Dr. Rangnekar, who is associate director of University of Kentucky's Markey Cancer Center, what these findings mean for the future is that it may not be necessary to use invasive or genetic approaches to inhibit the growth of cancer. Par-4, secreted inside the human body by the kidney, lung and prostate, can now be developed so as to inject the protein to treat cancer. Not only primary tumours that have spread to other tissues should be killed by Par-4 protein, Dr. Rangnekar told.

Increased par-4 protein in circulation, in the blood and serum of the super mice is one of the reasons they are reistant to cancer, he added. According to his team, a person is susceptible when the amount of this par-4 protien secreted by the cells of that individual may be low and inadequate.

"This needs to be tested on an individual basis. The next step is to test whether human cancer can be prevented or treated by increasing the amount of protein produced." And how will the team do that? "Either by injecting par-4 protein or by trying different diets," Dr. Rangnekar said. Reporting this breakthrough in the journal "Cell" on Friday. Dr. Rangnekar, added, "The novelty is that the par-4 molecule binds to its receptor GRP78 on the surface of the tumour cell and then triggers biological process called apoptosis or cell suicide, killing the cancer cells."

Is the finding new? Dr. Rangnekar said, "We knew previously that par-4 is present inside human tissues and cells. This new finding shows that it is also secreted and in circulation in humans, just like it is in circulation in the blood or serum of super mice."


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